[Skip to Content]
Access to paid content on this site is currently suspended due to excessive activity being detected from your IP address 54.205.0.26. Please contact the publisher to request reinstatement.
[Skip to Content Landing]
Views 281
Citations 0
Lab Reports
October 6, 2015

Stem Cell Model May Shed Light on Pathogenesis of Mental Illness

JAMA. 2015;314(13):1331. doi:10.1001/jama.2015.12350

Investigators at Brigham and Women’s Hospital in Boston have generated human induced pluripotent stem cell lines with mutations in the disrupted in schizophrenia 1 (DISC1) gene that have been associated with multiple major mental illnesses (Srikanth P et al. Cell Reports. doi:10.1016/j.celrep.2015.07.061 [published online August 20, 2015]).

Alterations in the gene are hypothesized to disrupt neural development in a way that predisposes an individual to conditions such as schizophrenia, bipolar disorder, and major depression by increasing vulnerability to other genetic and environmental risk factors.

First Page Preview View Large
First page PDF preview
First page PDF preview
×