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Lab Reports
October 6, 2015

Stem Cell Model May Shed Light on Pathogenesis of Mental Illness

JAMA. 2015;314(13):1331. doi:10.1001/jama.2015.12350

Investigators at Brigham and Women’s Hospital in Boston have generated human induced pluripotent stem cell lines with mutations in the disrupted in schizophrenia 1 (DISC1) gene that have been associated with multiple major mental illnesses (Srikanth P et al. Cell Reports. doi:10.1016/j.celrep.2015.07.061 [published online August 20, 2015]).

Alterations in the gene are hypothesized to disrupt neural development in a way that predisposes an individual to conditions such as schizophrenia, bipolar disorder, and major depression by increasing vulnerability to other genetic and environmental risk factors.

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