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To the Editor The APPAC trial1 successfully recruited and randomized a large number of patients with uncomplicated appendicitis into surgical or antibiotic treatment groups. Even though the results support antibiotic treatment as a viable alternative to surgery for uncomplicated appendicitis, such a change in practice needs to be viewed in the context of the global increase in antimicrobial resistance.2
Pollara G, Marks M. Treatment of Uncomplicated Acute Appendicitis. JAMA. 2015;314(13):1402. doi:10.1001/jama.2015.11420