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Comment & Response
October 6, 2015

Treatment of Uncomplicated Acute Appendicitis

Author Affiliations
  • 1Division of Infection and Immunity, University College London, London, England
  • 2Clinical Research Department, London School of Hygiene and Tropical Medicine, London, England
JAMA. 2015;314(13):1402. doi:10.1001/jama.2015.11420

To the Editor The APPAC trial1 successfully recruited and randomized a large number of patients with uncomplicated appendicitis into surgical or antibiotic treatment groups. Even though the results support antibiotic treatment as a viable alternative to surgery for uncomplicated appendicitis, such a change in practice needs to be viewed in the context of the global increase in antimicrobial resistance.2

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