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Comment & Response
October 6, 2015

Treatment of Uncomplicated Acute Appendicitis

Author Affiliations
  • 1Center for Surgical Outcomes Research, Nationwide Children’s Hospital, Columbus, Ohio

Copyright 2015 American Medical Association. All Rights Reserved. Applicable FARS/DFARS Restrictions Apply to Government Use.

JAMA. 2015;314(13):1401-1402. doi:10.1001/jama.2015.11426

To the Editor The use of a noninferiority design in the Appendicitis Acuta (APPAC) trial allowed for the assessment of primary outcomes specific to each treatment.1 However, we believe that the chosen outcomes were not equally patient-centric, leading to the erroneous conclusion that antibiotics did not meet the prespecified criterion for noninferiority compared with appendectomy.1

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