In Reply The APPAC trial tested the hypothesis that uncomplicated acute appendicitis can be successfully treated with antibiotics by comparing antibiotic therapy with emergency open appendectomy. There is an intrinsic difficulty in defining a common primary outcome for these dissimilar treatments. Although Drs Minneci and Deans advocate for more patient-centric outcomes, we aimed to identify a clear and concise definition of efficacy (ie, resolution of acute appendicitis) that would apply to both treatments.
Salminen P, Grönroos JM. Treatment of Uncomplicated Acute Appendicitis—Reply. JAMA. 2015;314(13):1403-1404. doi:10.1001/jama.2015.11441