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September 16, 1933


JAMA. 1933;101(12):941-942. doi:10.1001/jama.1933.02740370045021

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Vaccination Against Filtrable Viruses  Professor Lignières, who has attracted attention by his persistence in being the only scientist who regards the B C G vaccine of Professor Calmette as not free from danger, has been carrying on, of late, research on vaccination against diseases produced by filtrable viruses. While his research has considered only diseases of animals, it has an important bearing on general biology and marks an advance over the methods heretofore employed. Vaccination against diseases caused by a filtrable virus, by means of a specific serum, confers a strong immunity, but the duration of the immunity is only a few days. The method employed consists in injecting under the skin an amount of specific serum that is rather large with relation to the weight of the subject, and, at another point, a small quantity of virus. This vaccination is performed in a single stage. It provokes reactions that

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