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September 16, 1933

Sécrétion interne et régénérescence: Essais expérimentaux cliniques et chimico-biologiques sur les phénomènes de régénérescence dans des conditions physiologiques (sénilité) et pathologiques. Therapia protoformativa multispecifica.

JAMA. 1933;101(12):952. doi:10.1001/jama.1933.02740370056033

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The author justly condemns the misleading term "rejuvenation." He points out that the conceptions of Brown-Séquard, Voronoff, Steinach, Cavazzi and Doppler are based on neither scientific substrata nor sound clinical observation. He spent twelve years in studying the chemophysiology of the internal secretions of the embryo and asserts that he has isolated substances which, when injected into aging individuals, result in a definite regeneration of the affected tissues. This form of therapy Ischlondsky designates as "incretion treatment" or as "therapia protoformativa multispecifica." More than 400 cases were observed. Ischlondsky divides these into (a) senile persons and (b) young individuals suffering from disease. He condemns "substitution therapy" by hormones as practiced today. It should be replaced, he insists, by his "only true, sensible method." A careful perusal of the work fails to disclose the method of obtaining the "incretory substances" referred to, except that they are obtained from embryos in the

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