This article is only available in the PDF format. Download the PDF to view the article, as well as its associated figures and tables.
The Hypophysis and Diabetes
Dr. B. A. Houssay lectured recently at Montevideo, Uruguay, on the hypophysis and diabetes. He discussed his studies on experimental diabetes made in collaboration with Dr. Biasotti. While pancreatic diabetes in dogs is not modified by the removal either of the thyroid gland or of the medulla of the suprarenals, it is attenuated in intensity and its evolution is prolonged by removal of the hypophysis. Glycosuria and even diabetes is frequently associated with acromegaly. The association of diabetes with a thalamencephalic lesion is rare. Animals deprived of the hypophysis are very sensitive to the action of insulin. Dogs deprived of both the hypophysis and the pancreas may survive with a glycemia even during six months. In dogs with a lesion deeply localized in the tuber cinereum, diabetes has an evolution of the same intensity as that observed in control dogs deprived of the pancreas alone. These
BUENOS AIRES. JAMA. 1930;95(24):1846-1847. doi:10.1001/jama.1930.02720240056024