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In this book, which is based on the study of 300 cases, Warren again brings into focus the various phases of the pathology of diabetes. A consideration of the insular hypothesis is followed by the description of the histology of the normal pancreas. The lesions of the pancreas seen in diabetes are then described and compared with lesions observed in the pancreas of nondiabetic individuals. A conclusion at this point is important. "It is striking that practically any lesion found in the pancreas of diabetic individuals, either involving the island tissue, the acinar tissue or both, can be duplicated in the pancreas of nondiabetics." Only the greater frequency of such lesions in diabetic patients justifies their consideration as presumptive evidence of diabetes, and, without information of the previous clinical course or without studies of the glycogen distribution in other organs, the diagnosis of diabetes cannot be made. The complications of
The Pathology of Diabetes Mellitus.. JAMA. 1930;95(25):1936. doi:10.1001/jama.1930.02720250058037