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This small book fulfils the purpose, stated in the preface, "to give a general survey of the subject and its application to disease, keeping in mind the needs of those not versed in recent chemical physiology." The introduction offers a simple explanation of the acid-base equilibrium of the body and is followed by an elucidation of the reaction of the blood. Van Slyke's classification of disturbances of acid-base balance is explained and is followed by Haldane's classification. The body defenses against alkalosis and acidosis are detailed together with methods for their determination. The last two thirds of the book is occupied with an application of chemical physiology to clinical medicine. The essential chemical features of diabetes, nephritis, gastro-enteritis, cyclic vomiting, ketosis, salicylate poisoning, anesthesia acidosis, tetany and pyloric stenosis are presented and logical methods of treatment are suggested.
Acidosis and Alkalosis.. JAMA. 1933;101(17):1340. doi:10.1001/jama.1933.02740420060037