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A. H. D., a man, aged 29, seen at 2:30 a. m., Sept. 28, 1930, had wheals from 15 to 20 cm. in diameter over the body, legs, arms and face. The eyes were closed from swelling of the lids. These wheals were still growing and showed numerous large pseudopodia around the periphery. In the center of these wheals were small puncture wounds that apparently were due to insect bites or stings. The administration of epinephrine, ephedrine and cold baths caused the wheals and the intense itching that accompanied them to disappear after a few hours. Investigation of the bedding showed numerous bedbugs.
The patient stated that he felt fine when he went to bed. He noticed a slight biting, then intense itching and turned on the light. His eyes swelled shut within a few minutes.
The next morning the left eye was still closed, but the remainder of the
Churchill TP. URTICARIA DUE TO BEDBUG BITES. JAMA. 1930;95(26):1975. doi:10.1001/jama.1930.27210260001007b