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This is a careful report of an epidemic of 301 confirmed cases of encephalitis that occurred in Sheffield, in 1924. It is especially valuable on account of the high character of its authors and consists of (1) an epidemiologic report by F. E. Wynne; (2) a pathologic report by J. S. C. Douglas, and (3) a clinical report by A. J. Hall and A. Gurney Yates. Then there is an appendix on etiology by J. R. Perdrau. Among the many interesting points brought out are the following: In about one half of the cases the primary attack was mild; in one fifth, severe. While in a general way the milder types of primary attack produced the greater number of cases of complete recovery and the more severe attacks produced the cases of nonrecovery and death, there was an important exception; namely, that parkinsonism not infrequently followed an extremely mild acute
The Sheffield Outbreak of Epidemic Encephalitis in 1924.. JAMA. 1927;88(11):861-862. doi:10.1001/jama.1927.02680370089030