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Article
January 3, 1931

DOSAGE OF VIOSTEROL

Author Affiliations

Toronto. Associate Professor, Department of Physiology, University of Toronto.

JAMA. 1931;96(1):60. doi:10.1001/jama.1931.02720270062032

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Abstract

To the Editor:  —In reference to your editorials in The Journal, October 4 and November 22, I enclose a reprint which we believe offers some evidence for the view that vitamin D acts through the parathyroid glands, and that overdosage with viosterol is not without danger.[Comment.—The first editorial points out that there is a wide margin between the therapeutic dose of viosterol and the amount which produces definitely pathologic results; that in view of the present caution exercised in dosage the Council on Pharmacy and Chemistry has deemed it advisable to increase the concentration of viosterol in oil and in fortified cod liver oil; and that the source of the increased calcium in the circulation after overdosage with viosterol is probably in the bones rather than in an increased absorption. The second editorial comment points out the probability, based on recent experiments, of separating the toxic effects from

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