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Article
May 7, 1927

FAT EMBOLISM

JAMA. 1927;88(19):1484. doi:10.1001/jama.1927.02680450028013
Abstract

That the manifestations of fat embolism are not confined to the pulmonary vessels and the capillaries of the central nervous system, as is commonly assumed, was pointed out some time ago in The Journal.1 The kidneys and the liver may also become impaired in function because of the location of fat emboli in their tissues. The importance of the subject consequently acquires added emphasis through the larger number of organ groups that have come into the forefront of possible involvement. The most prevalent belief with respect to fat embolism has assigned the liberation of the objectionable fat particles into the blood stream to mechanical disturbance of fat depots, notably the bone marrow. A traumatic etiology of fat embolism can readily be demonstrated in many instances and by a variety of experimental procedures. Fractures of bones are among the most familiar forms of injury likely to be accompanied by the

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