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Article
May 7, 1927

THE SYMPTOMATOLOGY OF DISTURBANCES IN ACID-BASE BALANCE

JAMA. 1927;88(19):1485-1486. doi:10.1001/jama.1927.02680450029016
Abstract

Biochemical studies of the last few years aided by the modern refinements of physicochemical measurements have tended to show a remarkable compensatory function of the body toward influences that make for decided changes in the reaction of its tissues and fluids. This is conspicuously true of the blood, in which the conditions are evidently so adjusted that the hydrogen ion concentration ordinarily undergoes small alterations at most. Evidently the acid-base equilibrium is carefully maintained. According to Myers and Booher, 3 the normal range of ph probably lies between ph 7.35 and ph 7.43. This assumes a normal range of bicarbonate concentration at the same time. Values lower than ph 7.32 and higher than ph 7.47 are regarded by them as definitely abnormal. What degrees of variation in hydrogen ion concentration are threatening to life has not been clearly established, though they have been regarded by some writers

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