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JAMA Clinical Evidence Synopsis
November 3, 2015

Interventions for Hirsutism

Author Affiliations
  • 1Department of Dermatology, Leiden University Medical Centre, Leiden, the Netherlands
  • 2Bahrain Branch of Cochrane, Awali, Bahrain
JAMA. 2015;314(17):1863-1864. doi:10.1001/jama.2015.11743

Clinical Question  What medical therapies are associated with greatest efficacy and fewest adverse events for treating hirsutism?

Bottom Line  Oral contraceptive pills (OCPs) have been associated with improvement for mild hirsutism, as has flutamide (250 mg) twice daily and spironolactone for more severe cases. Finasteride and gonadotropin-releasing analogues are associated with inconsistent results and metformin is not associated with benefit.