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Lab Reports
November 3, 2015

Adipose Tissue: An HIV Reservoir With Inflammatory Potential

JAMA. 2015;314(17):1788. doi:10.1001/jama.2015.13106

New research indicates that adipose tissue likely plays an important role not only in chronic immune activation and inflammation during HIV infection, but also in viral persistence in some patients.

Investigators at Université Paris-Sud and their colleagues found that the adipose tissue of macaques infected with simian immunodeficiency virus (SIV) contained high densities of adipocytes, which store fat, and an increase in the mixture of cells called stromal vascular fraction (SVF) that contains macrophages and CD4+ T cells (Damouche A et al. PLOS Pathogens. doi:10.1371/journal.ppat.1005153 [published online September 24, 2015]).

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