Using genome-wide bisulfite sequencing of plasma DNA, investigators from China have developed a method for analyzing the major tissue contributors to circulating DNA (Sun K et al. Proc Natl Acad Sci U S A. doi:10.1073/pnas.1508736112 [published online September 21, 2015]. The method, which assesses DNA methylation patterns, is also useful for identifying the tissue of origin of genomic aberrations found in plasma DNA.
Hampton T. Plasma DNA Mapping May Have Broad Clinical Application. JAMA. 2015;314(17):1788. doi:10.1001/jama.2015.13933