Disability due to lower extremity peripheral artery disease is a major public health challenge in the 21st century. Peripheral artery disease affects an estimated 8 million men and women in the United States and more than 200 million men and women worldwide.1,2 Patients with peripheral artery disease have increased rates of cardiovascular events, greater walking impairment, and higher rates of mobility loss compared with people without peripheral artery disease.2,3 Because improved medical therapy for cardiovascular disease has reduced cardiovascular mortality rates, patients with peripheral artery disease are living longer with functional impairment and disability.
McDermott MM. Erasing Disability in Peripheral Artery DiseaseThe Role of Endovascular Procedures and Supervised Exercise. JAMA. 2015;314(18):1921–1923. doi:10.1001/jama.2015.15116