To the Editor The Prolonged Anticoagulation During Eighteen Months vs Placebo After Initial Six-month Treatment for a First Episode of Idiopathic Pulmonary Embolism (PADIS-PE)1 trial investigated extended duration of warfarin therapy after a first episode of unprovoked pulmonary embolism. The results may be biased by the inclusion of patients with both identified and unidentified thrombophilias.
Rhinehart ZJ, Rivera-Lebron B, George MP. Thrombophilia and the Risk of Recurrent Venous Thromboembolism. JAMA. 2015;314(18):1975-1976. doi:10.1001/jama.2015.12598