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January 25, 1941


Author Affiliations

New Haven, Conn.
From the Departments of Internal Medicine and Surgery, Yale University School of Medicine, and the Medical and Surgical Services of the New Haven Hospital.

JAMA. 1941;116(4):298-300. doi:10.1001/jama.1941.62820040004010b

The seriousness of staphylococcic meningitis is well known, and only scattered reports of recovery from this condition, numbering less than a dozen, have appeared in the literature. The methods of treatment have consisted of simple cisternal drainage,1 bacteriophage therapy,2 administration of gentian violet,3 sulfanilamide (or azosulfamide) therapy,4 or combinations of these methods. Recently Dietel and Kaiser5 made note of the recovery of a child with staphylococcic meningitis following therapy with sulfathiazole.

Sulfathiazole, synthesized by Fosbinder and Walter6 and Lott and Bergeim7 has attracted attention in the clinical treatment of staphylococcic infections8 and its efficacy against the staphylococcus has been attested experimentally by in vivo9 and in vitro10 methods.

It has been recently shown11 in this clinic, however, that sulfathiazole, unlike the other sulfonamide derivatives, does not readily diffuse into the noninflammatory cerebrospinal fluid. This finding immediately suggested the possible

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