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January 25, 1941


JAMA. 1941;116(4):311. doi:10.1001/jama.1941.02820040045015

The pharmacologic literature on various chronic toxic reactions with sulfonamide derivatives in the experimental animal has been scarce and unsatisfactory; indeed, many physicians believe that at least some of these phenomena cannot be produced experimentally. Thus there has occurred a tendency to try new derivatives clinically before satisfactory pharmacologic evidence has accumulated.

Among the reasons for this attitude is the fact that experiments on the acute toxicity of these drugs have been taken as a standard far too rigidly for the repeated administration of the drugs to man. The toxicity of single doses is not evidence of chronic toxicity. Pharmacologists have seldom given sufficient consideration to experiments involving long-continued administration of remedies. Gradually, however, this dearth of experiments is being rectified.

As most of the experimental work involving the therapeutic action of these drugs has been conducted on mice, rats and rabbits, it is not surprising that these species were

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