Headache is undoubtedly among the most frequent ills to which the human flesh is heir. It is a complaint which has been known to mankind since the dawn of antiquity. Few contributions, however, have marked medical progress in this field.
It is not my purpose to review or consider the differential diagnostic features of the various types of headaches and head pains which have been recorded in the literature but rather to describe a new syndrome of vascular headache and to report the results of treatment with histamine. Other less well defined types of headaches have also been treated with histamine and the results will be reported.
This new syndrome of vascular headache, which MacLean, Craig and I1 tentatively called "erythromelalgia of the head" and which I shall call "histaminic cephalgia" hereafter, was first encountered and recognized at the Mayo Clinic in September 1937. At that time the syndrome
HORTON BT. THE USE OF HISTAMINE IN THE TREATMENT OF SPECIFIC TYPES OF HEADACHES. JAMA. 1941;116(5):377–383. doi:10.1001/jama.1941.02820050021005