Although multiple sclerosis (MS) has been traditionally viewed as a T-cell–driven disease, investigators have now found that a type of B cell may drive inflammation associated with the condition (Li R et al. Sci Transl Med. 2015;7:310ra16).
A team led by researchers at McGill University’s Montreal Neurological Institute discovered that a subset of memory B cells, which are proinflammatory and express granulocyte macrophage–colony stimulating factor (GM-CSF), is increased in frequency and more readily induced in patients with MS compared with individuals without the disease.
Hampton T. B Cells Fuel Inflammation in Multiple Sclerosis. JAMA. 2015;314(21):2226. doi:10.1001/jama.2015.16086