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JAMA Clinical Evidence Synopsis
December 8, 2015

Interventions for Rosacea

Author Affiliations
  • 1Department of Dermatology, Leiden University Medical Centre, Leiden, the Netherlands
  • 2Bahrain Branch of Cochrane, Awali, Bahrain

Copyright 2015 American Medical Association. All Rights Reserved. Applicable FARS/DFARS Restrictions Apply to Government Use.

JAMA. 2015;314(22):2403-2404. doi:10.1001/jama.2015.15287

Clinical Question  Which interventions are associated with highest efficacy and fewest adverse events for treating rosacea?

Bottom Line  There is high-quality evidence that topical brimonidine, azelaic acid, and ivermectin, as well as oral doxycycline and isotretinoin, are associated with improvements in rosacea. Lower-quality evidence is available for topical metronidazole, oral tetracycline, laser and light-based therapy, and topical cyclosporine for ocular rosacea. Most treatments are not associated with higher adverse event rates than placebo.