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January 24, 1931


JAMA. 1931;96(4):290. doi:10.1001/jama.1931.02720300060030

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To the Editor:  —I have read the letter which Professor Calmette sent you for publication and on which you ask me to comment (The Journal, January 3, p. 58).I agree with Calmette as to the harmlessness of his culture when it is fed or injected into infants, and is kept as he directs. Dr. Kereszturi has under my general supervision been using the B C G vaccine throughout four years. During that time, more than 300 infants have been vaccinated and we have never observed the slightest harm to any who received the vaccine orally; and in those infants who received it subcutaneously, we observed nothing deleterious except a few small "cold abscesses," which in every case entirely healed.Concerning Calmette's belief that by growing the B C G vaccine on special mediums Petroff does not cause a dissociation into two types of bacillus, one of which is practically

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