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News From the Food and Drug Administration
December 15, 2015

Antibody Approved for Asthma

JAMA. 2015;314(23):2497. doi:10.1001/jama.2015.16802

Mepolizumab, marketed as Nucala, has been approved for use with other asthma medications as maintenance therapy for patients with asthma who have a history of exacerbations despite taking their current asthma treatment.

The drug is a humanized interleukin-5 antagonist monoclonal antibody produced by recombinant DNA technology in Chinese hamster ovary cells. Mepolizumab, which is given by injection every 4 weeks, reduces severe asthma attacks by reducing blood levels of eosinophils (http://1.usa.gov/20wB823).

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