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Comment & Response
January 12, 2016

Electronic Health Records as Sources of Research Data—Reply

Author Affiliations
  • 1Department of Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania; and Associate Editor, JAMA
JAMA. 2016;315(2):202. doi:10.1001/jama.2015.15422

In Reply I agree with Dr Opmeer that an important barrier to the conduct of high-quality RCTs nested in the EHR will be the quality of the EHR itself. I specifically noted in the Viewpoint that this would arguably be the greatest challenge.

Opmeer focuses on lack of completeness, validity, and reliability of clinical data in the EHR. Even though I share his concerns, I would point out that these same threats already compromise all clinical research.

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