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April 5, 1941

Znachenie vypadeniya funktsii selezenki v razvitii kholesterinemii i fosfatidemii, eksperimentalnoe issledovanie k voprosu o mozgovom proiskhozhdenii lipoidemii

Author Affiliations

[By] V. I. Glod. [Role of Exclusion of Splenic Function in Development of Cholesterolemia and Phosphatidemia; Experimental Studies on Problem of Cerebral Origin of Lipoidemia.] Cloth. Price, 4 rubles, 25 kopecks. Pp. 64, with 12 illustrations. Moscow & Leningrad: Narkomzdrav SSSR; Gosudarstvennoe Izdatelstvo Meditsinskoy Literatury "Medgiz," 1940.

JAMA. 1941;116(14):1607. doi:10.1001/jama.1941.02820140119039

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This brief monograph by V. I. Glod, working in the First Moscow Medical Institute, has to do with the effect of splenectomy in dogs and in cats on the development of cholesteremia and phosphatemia. The author had established in his experiments that both cholesteremia and phosphatemia following the removal of the spleen have their origin in the brain. Hypercholesteremia and phosphatemia observed in splenectomized animals for twenty-one months exhibited an alternating character, periods of increase of cholesterol and phosphorus blood levels being accompanied by a corresponding increase in these substances in the blood of the efferent vessels of the brain, and the reverse. Destructive changes in the brains of dogs and cats were observed as the result of removal of the spleen. The author regards hypercholesteremia and phosphatemia following a splenectomy as a result of intoxication producing dystrophic changes in the brain corresponding to a reaction on the part of

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