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Article
July 9, 1927

VACCINATION OF THE NEW-BORN AGAINST TUBERCULOSIS WITH BACILLUS CALMETTE GUÉRIN

JAMA. 1927;89(2):115-116. doi:10.1001/jama.1927.02690020039014

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Abstract

The history of the vaccination of new-born infants against tuberculosis with Bacillus Calmette Guérin (abbreviated to B C G) since July 1, 1924, in France and other countries over a period of two and one-half years to Jan. 1, 1927, has just been reviewed by Professor Calmette with his co-workers Guérin, Nègre and A. Boquet at the Pasteur Institute in Paris. Indeed, the entire March issue of the Annals of the Pasteur Institute, consisting of 368 pages, is devoted to this subject. The vaccine is a living tubercle bacillus of bovine origin rendered avirulent for all animals by 230 passages on bovine bile medium. While the authors quote the reports of other workers and use these as reasons for suggesting the vaccination of newborn children with B C G, they depend chiefly on their own experimental work as the prime reason.

For the preparation of the vaccine, the B C

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