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Article
February 7, 1931

INFLUENCE OF PARATHYROID EXTRACT ON BONE SALTS

JAMA. 1931;96(6):443. doi:10.1001/jama.1931.02720320043010
Abstract

Among the phenomena resulting from the extirpation of the parathyroid glands, the decrease in concentration of the calcium in the blood is striking and characteristic. The decrease after parathyroidectomy may reach from 40 to 50 per cent. In young experimental animals, removal of the parathyroids results in the deposition of dentin, enamel and bone containing less calcium than occurs in similar tissue of control animals.1 In a recent study, Speed and Rider2 have reinvestigated the correlation between the decreased level of calcium in the blood and the healing of fractures after parathyroidectomy. Chemical examination of the fractures after three weeks revealed some callus formation but doubtful union, while after six weeks there was more or less firm union of the fractured bone. Firm bony union occurred in three weeks in the otherwise normal control animals. These observations were confirmed by roentgen examination. Histologic examination of the bone and

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