To the Editor The ancillary study by Dr Chew and colleagues1 on cognitive function from the AREDS2 trial and the accompanying Editorial2 do not do justice to the potential benefits of omega-3 LCPUFAs (docosahexaenoic acid [DHA] with or without eicosapentaenoic acid [EPA]) on cognition in adults with mild memory complaints. The authors of the Editorial supported a Mediterranean diet but discouraged use of any supplements. In fact, a significant body of data supports improved cognition with the use of DHA obtained naturally from fish or from supplements for individuals with mild memory complaints.
Yurko-Mauro K, Nelson E, Salem N. Oral Nutrient Supplementation and Cognitive Function. JAMA. 2016;315(5):516. doi:10.1001/jama.2015.16452