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Comment & Response
February 2, 2016

Oral Nutrient Supplementation and Cognitive Function—Reply

Author Affiliations
  • 1Clinical Trials Branch, National Institutes of Health, Bethesda, Maryland
  • 2Neuroepidemiology Section, National Institutes of Health, Bethesda, Maryland
  • 3Moran Eye Center, University of Utah, Salt Lake City
JAMA. 2016;315(5):516-517. doi:10.1001/jama.2015.16467

In Reply The AREDS2 trial provided a unique opportunity to evaluate the effects of oral supplementation on cognition. The limitations of our study included testing in a well-nourished, well-educated, select population affected with age-related macular degeneration. We noted the restricted generalizability of the results to this population and the possibility that the doses and ratios of various omega-3 LCPUFAs were inappropriate.

Concerning the remarks of Dr Renzi-Hammond and colleagues, our study was designed to evaluate the main effects of the individual nutrients, specifically omega-3 LCPUFAs. We agree that this was not a placebo-controlled study. We described the fact that the majority of participants were using some form of AREDS supplements that contained antioxidant vitamins C, E, and beta-carotene, which were tested in previous trials of cognition with no definitive beneficial effects.1

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