For many years I have followed the various vaccine and chemical treatments for chronic sinusitis. The vaccines have been used both hypodermically and locally as a filtrate with disappointing results. Every new treatment from the Carrel-Dakin down to the recent treatment with sulfanilamides and azosulfamide solutions has been used in the sinuses, and while the 2.5 per cent solution of azosulfamide used as a spray in the nose and throat has been giving favorable results in infections of acute involvement, such as in the recent epidemic of influenza, and apparently is a preventive to a certain extent in this infection, no results were obtained with it in the treatment of chronic infections of the sinuses.
Cultures taken of material from the sinus in many cases of chronic sinusitis over a long period have shown that the predominating organism is the staphylococcus, so that when sulfamethylthiazole was introduced it seemed especially
TURNBULL FM. INTRANASAL THERAPY WITH SODIUM SALT OF SULFATHIAZOLE IN CHRONIC SINUSITIS. JAMA. 1941;116(17):1899-1900. doi:10.1001/jama.1941.02820170017007