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Article
March 10, 1934

THE ETIOLOGY OF PRIMARY GRANULOCYTOPENIA (AGRANULOCYTIC ANGINA)

Author Affiliations

MILWAUKEE
From the Department of Medicine, Marquette University School of Medicine.

JAMA. 1934;102(10):755-759. doi:10.1001/jama.1934.02750100021006
Abstract

In 1922, when Schultz1 described the syndrome which he called "agranulocytosis" and which later was called "agranulocytic angina,"2 he suggested that it might be the result of a depressant effect on the bone marrow of an unknown micro-organism or possibly of an unknown chemical agent. Extensive search for an organism capable of producing such an effect has met little success. Salmonella suipestifer,3 Bacillus pyocyaneus4 and occasional organisms isolated from human cases have produced leukopenia with granulopenia in experimental animals but not in a manner entirely comparable to the syndrome seen in the human being. Nor has any organism thus far been found to occur constantly or even frequently in the clinical cases. Recently Dennis5 has attempted to incriminate focal infections by introducing various organisms in the experimental animal in a manner intended to simulate that type of infection in man and has found a tendency

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