Reports of deaths due entirely to transfusion of whole blood are fairly rare. Reports of deaths due entirely to transfusion of plasma are still more rare. I have been unable to find any report of a fatality due to plasma transfusion in the English literature between the years 1927 and 1940. The lack of such reports may be explained by the only too recent enthusiasm over and use of transfusions of plasma.
REPORT OF CASE
A boy aged 4 years entered the hospital on July 31, 1940 because of severe edema. He had been perfectly well until one week before entry, when he acquired a cold the only manifestation of which was a running nose. He did not have a cough, sore throat, rash, articular pains, dyspnea or pains in the chest. Four days before entry he had edema of the ankles which gradually became generalized. One day before entry
Mayner F. DEATH FROM TRANSFUSION OF PLASMA. JAMA. 1941;116(18):2015–2016. doi:10.1001/jama.1941.62820180003006b