Whenever a new drug makes its appearance, especially one that theoretically should prove of great usefulness, there is an immediate reaction among clinicians of overenthusiasm in judging its value. Such overenthusiasm has one good effect in that the use of the drug becomes widespread; numerous reports appear on its clinical application, and from these one arrives at a more correct judgement of its value. This report of the use of ephedrine in asthma and hay-fever is offered to aid in such an evaluation.
The work of Chen and Schmidt1 first suggested the used of ephedrine in asthma and allied conditions. These authors pointed out the similarity of its action to epinephrine and its added advantages over the latter of a more prolonged action and a definite effectiveness on oral administration.
At this point it may be interesting to relate our efforts to obtain the drug for clinical use when
PINESS G, MILLER H. EPHEDRINE IN ASTHMA AND HAY-FEVERVALUE OF EPHEDRINE AS SHOWN BY ITS USE IN ONE HUNDRED AND TEN CASES OF ASTHMA AND TWENTY CASES OF HAY-FEVER. JAMA. 1927;89(7):515. doi:10.1001/jama.1927.02690070025008