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JAMA Clinical Evidence Synopsis
February 23, 2016

Topical Nonsteroidal Anti-inflammatory Drugs for Acute Musculoskeletal Pain

Author Affiliations
  • 1Pain Research and Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, England
JAMA. 2016;315(8):813-814. doi:10.1001/jama.2016.0249

Clinical Question  Are topical nonsteroidal anti-inflammatory drugs (NSAIDs) associated with reduced pain intensity in acute musculoskeletal conditions, but without increased adverse events?

Bottom Line  When treating musculoskeletal conditions such as sprains, strains, and contusions, topical NSAIDs are associated with greater pain relief, but are not associated with an increase in adverse events compared with placebo.