Atopic dermatitis (AD) is a pruritic chronic inflammatory skin disease that affects 15% to 20% of children and is often accompanied by sleep disturbances. According to findings from a recent randomized trial, melatonin was safe and effective in improving the severity of atopic dermatitis (AD) in children and adolescents while also reducing sleep disturbance (Chang YS et al. JAMA Pediatr. 2016;170:35-42).
Forty-eight children (aged 1-18 years) with AD and with sleep disturbances (>3/week) were randomized 1:1 to 2 groups: either melatonin (3 mg/d) or placebo treatment for 4 weeks. After a 2-week washout period, the melatonin group received placebo, and the placebo group received melatonin for another 4 weeks. Participants continued with their original treatments for AD during the trial.
Slomski A. Melatonin to Improve Skin and Sleep in Pediatric Dermatitis. JAMA. 2016;315(8):742. doi:10.1001/jama.2016.1083