An estimate of the results of treatment of central nervous system syphilis is an extremely complex problem, involving prolonged observation of treated patients, and the correlation of intricate clinical data with equally complicated laboratory investigations. Adequate studies free from controversial bias, comparable to the detailed information now available from many sources as to treatment results in early syphilis, have been lacking until the authoritative discussions of Fordyce1 and of Stokes and Shaffer2 appeared. In 1924 these workers each published papers, the one describing treatment methods and results in 405 cases, and the other in 442 cases of neurosyphilis. Their results (except for certain data as to general paralysis) are the most complete available in the literature, and should be familiar to every one who attempts to treat neurosyphilis.
In this paper I will outline briefly the methods of treatment in use in the syphilis division of the Medical
MOORE JE. THE TREATMENT OF CENTRAL NERVOUS SYSTEM SYPHILIS. JAMA. 1927;89(8):588-594. doi:10.1001/jama.1927.02690080020009