In an article a year ago on the relation of anemia, primary and secondary, to vitamin A deficiency, we 1 reported on the experimental production of a blood picture in animals, which in all essential details showed a striking similarity to human pernicious anemia. On the basis of this work we reached the conclusions that:
The fat soluble vitamin A is essential for normal blood regeneration.
The addition of vitamin A to the diet of animals long depleted in their vitamin A reserve brings about rapid formation of new blood cells.
A definite relationship exists between a state of chronic vitamin deficiency and certain anemias in man, and
The routine use of a rationally balanced diet rich in vitamins A, B and C had proved itself of decided value in the blood regeneration of patients suffering from pernicious anemias and is the most promising procedure in the treatment of this
KOESSLER KK, MAURER S. TREATMENT OF PERNICIOUS ANEMIA WITH A HIGH CALORIC DIET, RICH IN VITAMINS. JAMA. 1927;89(10):768-774. doi:10.1001/jama.1927.02690100030008