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Lab Reports
March 1, 2016

Scientists Identify Genes Critical to Development of Leukemia

JAMA. 2016;315(9):860. doi:10.1001/jama.2016.1486

New research suggests that 2 genes involved in epigenetic programming may be attractive targets against acute myeloid leukemia (AML), the most common form of leukemia among adults (Cheung N et al. Cancer Cell. 2016;29[1]:32-48).

Investigators at King’s College London found that PRMT1and KDM4C, encoding a methyltransferase and histone demethylase, respectively, work in tandem to regulate chromosomes’ histone methylation and alter gene expression in a way that can cause blood cells to become cancerous. PRMT1 was necessary but not sufficient for inducing AML: co-recruitment of KDM4C was also needed for epigenetic reprogramming.

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