New research suggests that 2 genes involved in epigenetic programming may be attractive targets against acute myeloid leukemia (AML), the most common form of leukemia among adults (Cheung N et al. Cancer Cell. 2016;29:32-48).
Investigators at King’s College London found that PRMT1and KDM4C, encoding a methyltransferase and histone demethylase, respectively, work in tandem to regulate chromosomes’ histone methylation and alter gene expression in a way that can cause blood cells to become cancerous. PRMT1 was necessary but not sufficient for inducing AML: co-recruitment of KDM4C was also needed for epigenetic reprogramming.
Hampton T. Scientists Identify Genes Critical to Development of Leukemia. JAMA. 2016;315(9):860. doi:10.1001/jama.2016.1486