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The widespread use of thiamine hydrochloride parenterally makes this report of acquired sensitivity to the substance of some clinical interest.
REPORT OF CASE
A white married woman aged 72, who had no prior history of allergic symptoms, was advised by her physician in September 1940 to take thiamine hydrochloride subcutaneously each day for ten days. This was administered in 25 mg. doses, and at the expiration of the ten day period the interval was increased to seven days. Eight injections were given, one each week, when she was advised to discontinue medication. The patient felt so well that she consulted a physician in a different city and discussed the possibility of continuing thiamine, since she had had such definite benefits. He acquiesced and gave her weekly injections of 25 mg. for eight or ten more doses. The patient fell and fractured the left radius at this time, and the thiamine
Laws CL. SENSITIZATION TO THIAMINE HYDROCHLORIDE. JAMA. 1941;117(3):176. doi:10.1001/jama.1941.72820290004005c