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JAMA Guide to Statistics and Methods
March 8, 2016

Time-to-Event Analysis

Author Affiliations
  • 1Department of Emergency Medicine, Harbor-UCLA Medical Center, Torrance, California
  • 2Los Angeles Biomedical Research Institute, Torrance, California
  • 3David Geffen School of Medicine at UCLA, Los Angeles, California
  • 4Berry Consultants LLC, Austin, Texas
JAMA. 2016;315(10):1046-1047. doi:10.1001/jama.2016.1825

Time-to-event analysis, also called survival analysis, was used in the study by Nissen et al1 published in this issue of JAMA to compare the risk of major adverse cardiovascular events (MACE) in a noninferiority trial of a combination of naltrexone and bupropion vs placebo for overweight or obese patients with cardiovascular risk factors. The authors used a type of time-to-event analysis called Cox proportional hazards modeling to compare the risk of MACE in the 2 groups, concluding that the use of naltrexone-bupropion increased the risk of MACE per unit time by no more than a factor of 2.

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