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JAMA Clinical Guidelines Synopsis
March 8, 2016

Prevention, Diagnosis, and Treatment of Postthrombotic Syndrome

Author Affiliations
  • 1Division of Consultative Medicine, Mayo Clinic, Scottsdale, Arizona
  • 2Division of Preventive, Occupational, and Aerospace Medicine, Mayo Clinic, Scottsdale, Arizona
  • 3Section of General Internal Medicine, University of Chicago, Chicago, Illinois
JAMA. 2016;315(10):1048-1049. doi:10.1001/jama.2016.0225

Postthrombotic syndrome is a spectrum of clinical signs and symptoms occurring in the setting of previous DVT. Manifestations range from lower extremity edema and hyperpigmentation in mild cases to lipodermatosclerosis (acute or chronic fibrosis of the skin with erythema or hyperpigmentation), atrophie blanche (avascular white fibrotic plaques), and venous ulcers in the most severe cases. Symptoms vary but typically include lower extremity pain, heaviness, and itching. The syndrome is estimated to occur in 20% to 50% of patients with DVT and is associated with lower health-related quality of life scores than arthritis, chronic lung disease, and diabetes.1

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