If one considers the many cases in which varicose veins are treated by the injection of sclerosing solutions, the dreaded complication of pulmonary embolism is relatively uncommon. Pennoyer1 in 1930 stated that only 4 cases had been reported up to that time; he stated further that in all these cases injection may have been done in the presence of acute or subacute phlebitis. Since 1930 2 more cases have been reported in this country and several have appeared in the foreign literature. Since 400,000 cases had been reported in which injection had been done, the possibilities of such a complication seem to be almost nil.
In 1928 McPheeters and Rice2 reported 7 deaths in a series of 53,000 cases of injection therapy; Kettel3 reported 20 deaths in a series of 60,000 cases, mortalities of 0.0025 per cent and 0.033 per cent respectively. These figures represent the combined
Nunn LL, Harrison JH. DEATH FROM PULMONARY EMBOLISM FOLLOWING THE INJECTION OF VARICOSE VEINS. JAMA. 1941;117(5):347-348. doi:10.1001/jama.1941.72820310003007b