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Article
June 2, 1934

THE ESTIMATION OF VITAMIN C

JAMA. 1934;102(22):1852. doi:10.1001/jama.1934.02750220030012
Abstract

The importance of a supply of antiscorbutic substances in the diet was appreciated long before the development of knowledge concerning vitamins. Scurvy was recognized as a true deficiency disease, and the belief was fortified when it became possible to develop the malady experimentally in animals and to avert or cure it by suitable dietary supplements. In the "alphabet of vitamins" the unidentified antiscorbutic factor was designated as vitamin C. On the basis of experimental and empirical clinical observation great progress has been made in the elimination of scurvy through well established principles of preventive medicine. Almost every child is now supplied with antiscorbutic foods. Infantile scurvy has all but disappeared. Recently two incidents have added to the knowledge of vitamin C. Foremost is the discovery of the chemical nature of this organic food accessory. It is clearly recognized as one of the hexuronic acids, designated as ascorbic acid—a compound that

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