June 2, 1934


JAMA. 1934;102(22):1852-1853. doi:10.1001/jama.1934.02750220030013

Perhaps the most striking manifestations of lead poisoning are those associated with an impaired nervous mechanism. Lead intoxication may be followed by a variety of neurologic symptoms, such as tremor, transient paralysis, convulsions, vertigo, temporary blindness, headache, insomnia, and mental lethargy or other disturbances. A recent report by Cone, Russel and Harwood1 further incriminates this element as a neurotoxic substance by the suggestion that it may be an etiologic agent in multiple sclerosis of the exacerbating and remitting type. This conclusion was based on the finding of appreciable quantities of lead in the cerebrospinal fluid, brain, spinal cord and bones of a number of patients with this disease. In only a few instances did the case histories indicate the possibility of a previous exposure to undue amounts of lead; therefore there had undoubtedly occurred a slow chronic absorption of amounts too small to produce toxic symptoms. In several

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