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Article
October 15, 1927

LOCAL SPECIFIC TREATMENT OF EXPERIMENTAL PNEUMOCOCCUS MENINGITIS

Author Affiliations

NEW YORK
From the Laboratories of the Rockefeller Institute for Medical Research.

JAMA. 1927;89(16):1316-1317. doi:10.1001/jama.1927.02690160024007

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Abstract

Pneumococcus meningitis is recognized as a highly fatal disease. In spite of rare reports of recovery, the mortality closely approaches 100 per cent. It is still uncertain whether the very occasional reported instances of recovery are not cases of incomplete or incorrect diagnosis. With a relative mortality from this form of meningeal infection so great, every effort should be made to achieve a treatment, although drastic, which may in some degree mitigate its fatality. During the past year our attention has been directed toward the study of the means of production, nature of the pathologic changes, and modes of treatment of type I pneucoccal meningitis in animals. After a number of trials, dogs were selected as most suitable for the experiments. Cognizance has, of course, been taken of the fact that in man pneumococcus meningitis usually is a concomitant of secondary infection in association with pneumonia or another distant focal

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