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To the Editor In their Editorial, Drs Keating and Pace1 reviewed updated breast cancer screening recommendations from the American Cancer Society (ACS). I respectfully disagree with their opening statement: “there is uncertainty about the magnitude of mammography’s benefits and harms.” Multiple randomized clinical trials and meta-analyses consistently demonstrate statistically significant mortality reductions of 20% to 30% in all age groups invited to screening mammography.2 Well-designed population-based observational studies of screening demonstrate mortality reductions of up to 48% for women older than 40 years who are actually screened.3
Moy L. Screening Mammography and Age Recommendations. JAMA. 2016;315(13):1404-1405. doi:10.1001/jama.2015.19072