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September 27, 1941


Author Affiliations

From the Endocrine Clinic, Department of Medicine, New York Post-Graduate Medical School and Hospital, Columbia University.

JAMA. 1941;117(13):1068-1074. doi:10.1001/jama.1941.02820390010004

Within the past few years the literature on testosterone has become voluminous. In large part it deals with laboratory experiments, animal studies and the like. Carefully controlled clinical observations over long periods of time have been comparatively few. Still, the ultimate goal is the actual clinical application, for without such its importance is reduced and its value largely academic. In our clinic we have treated a large number of patients suffering with a wide diversity of conditions, including the postcastration status, eunuchoidism, hypogonadism of other types such as Lorain-Levi infantilism and hypopituitarism, impotence and others. For clarity and brevity only selected cases will be reported at this time, others being left for later communications.

This report deals with observations on patients chosen from the "hypogenital groups," numbering in all 60, of whom 30 have been given further treatment by implantation, 30 having been treated by injections only. The 30 patients

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